DetectX® Allopregnanolone ELISA试剂盒用于检测各种样品中的Allopreganolone。

检测类型:Competitive ELISA

样本类型:Urine, Extracted Serum, Extracted Plasma (EDTA and Heparin), Dried Feces, Tissue Culture Media

灵敏度:129.7 pg/mL

适应物种:Allopregnanolone在不同物种间相同

检测时间:2.5小时或过夜

样品数/板:39 in Duplicate

读数:Colorimetric, 450 nm

DetectX® Allopregnanolone ELISA试剂盒提供有Allopregnanolone标准品以生成测定的标准曲线，所有样品应从标准曲线中读出。将标准品或稀释的样品吸移到包被有抗体的微孔板中以捕获小鼠抗体。将Allopregnanolone-过氧化物酶结合物添加到孔中，通过向每个孔中添加别孕烯醇酮单克隆抗体从而启动结合反应。

Allopregnanolone (3α-hydroxy-5α-pregnan-20-one, THP, THPROG) is a prototypic neurosteroid present in the blood and the brain. It is a metabolite of progesterone and potent modulator of GABAA receptors. Allopregnanolone has pharmacological properties including anxiolytic and anticonvulsant activity. The biosynthesis of allopregnanolone involves the conversion of progesterone into 5α-dihydroprogesterone by the enzyme 5α-reductase type I. Subsequently, 3α-hydroxysteroid oxidoreductase isoenzymes convert this intermediate into allopregnanolone. Anxiety and depression are common side effects of 5α-reductase inhibitors such as finasteride and dutasteride, and they are believed to be caused, in part, by the prevention of the endogenous production of allopregnanolone. Allopregnanolone aids neurogenesis and has been found to reverse neuron proliferative deficit and cognitive deficits in mouse models of Alzheimer’s disease.

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