Factor VIII抗体

产品名称:
Murine Anti-Factor VIII抗体
Clone GMA-8011

描述:
Factor VIII (FVIII) is a heterodimer consisting of a heavy chain (ranging in mass from 90 to 200 kDa) bound via metal ions to a light chain (80 kDa). In plasma, FVIII circulates in an inactive form bound to von Willebrand factor. Following activation by factor Xa or thrombin, factor VIIIa can function as cofactor for the enzyme factor IXa in the activation of factor X in the presence of phospholipid and Ca2+. Absent or defective FVIII is the cause of the X-linked recessive bleeding disorder hemophilia A. GMA-8011 (also known as 2A9 or 2A9.1B)1 recognizes the C1 domain of FVIII, inhibits FVIII activation and binding to VWF and phospholipids2, and displays subnanomolar binding to FVIII by surface plasmon resonance2.


物种反应性: Human

来源: Murine

特异性: C1 domain

免疫原: B-domain deleted recombinant Human Factor VIII

同型: IgG2a

应用
ELISA: Binds the C1 domain of recombinant human factor VIII in solid-phase ELISA.

Immunoblotting: Not recommended.

Inhibition: Weakly inhibitory in Bethesda assay.