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Murine Anti-Factor IX(Clone GMA-124)
货号:GMA-124 | 规格:0.5 mg | 价格:¥0.00 | 品牌:GMAb
Green Mountain Antibodies Murine Anti-Factor IX/小鼠Factor IX抗体(Clone GMA-124)与FIX结合,并以ELISA和免疫印迹的形式检测FIXa的轻链。

Murine Anti-Factor IX
Clone GMA-124

Factor IX (FIX) is a vitamin K-dependent zymogen that plays an essential role in the coagulation cascade leading to thrombus formation. In the presence of calcium, activated Factor IX (FIXa) complexes with Factor VIIIa on phospholipid surfaces to create the tenase complex, which converts Factor X to its activated form. Absent or defective FIX is the cause of the X-linked recessive bleeding disorder hemophilia B. GMA-124 binds to FIX and detects the light chain of FIXa in both ELISA and Western blot formats. In addition, bound GMA-124 captures FIX by bio-layer interferometry.

物种反应性: Bovine, Human, Porcine, Rat

来源: Murine

特异性: Light chain of FIX/FIXa

免疫原: Human Factor IX

同型: IgG1


应用
ELISA: Binds immobilized Human, Rat, Porcine, and Bovine FIX, Human FIXa

Immunoblotting: Western blot detects Human FIX, light chain of Human FIXa under reduced conditions.

Inhibition: Does not prolong plasma clot time in APTT clotting assay.

BLI: KD=50 nM (kdis=4.38x10-3 sec-1) by bio-layer interferometry.



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